Iron Hand
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Iron Hand
Iron Hands is a large, bulky cyborg Pokémon that looks like a futuristic sumo wrestler. The head crest is a deep blue with ten black lines connecting across it. The head is light grey with cylinder like ears. The two eyes are yellow within a black faceplate. The upper half of their body is colored light gray resembling a light armor gear with two bright yellow holes with white spots on each side of where the shoulder would be. Also connected to it is a grey belt with three yellow square armor-like pieces on each side with white spots as well. The lower half is grey with several black line markings. The half-sphere legs are colored dark blue which are connected to small yellow rectangles with white spots. The black feet are shaped like shoes with one small, yellow rectangle with white spots connected to each foot. It has two giant, three fingered hands which it uses. The back side of their hands is light grey with a yellow circle in the center with three white spots each. The front is four large, bight yellow rectangles connected to each other and black lines. The rectangles also have several white spots as well.
According to an article from a May issue of Occulture magazine, Iron Hands got its name from an iron-handed entity described in the Violet Book. It is said to have fists that move independent of its body and to be capable of throwing large, fast-moving vehicles. An unproven theory claims that Iron Hands was once an athlete who became mortally wounded but was kept alive by being made into a cyborg. It strongly resembles Hariyama, though why this is remains unanswered.
The role of iron as a critical nutrient in pathogenic bacteria is widely regarded as having driven selection for iron acquisition systems among uropathogenic Escherichia coli (UPEC) isolates. Carriage of multiple transition metal acquisition systems in UPEC suggests that the human urinary tract manipulates metal-ion availability in many ways to resist infection. For siderophore systems in particular, recent studies have identified new roles for siderophore copper binding as well as production of siderophore-like inhibitors of iron uptake by other, competing bacterial species. Among these is a process of nutritional passivation of metal ions, in which uropathogens access these vital nutrients while simultaneously protecting themselves from their toxic potential. Here, we review these new findings within the current understanding of UPEC transition metal acquisition.
The paradigm of cancer stem cells (CSCs) defines the existence of cells exhibiting self-renewal and tumor-seeding capacity. These cells have been associated with tumor relapse and are typically resistant to conventional chemotherapeutic agents. Over the past decade, chemical biology studies have revealed a significant number of small molecules able to alter the proliferation of these cells in various settings. The natural product salinomycin has emerged as the most promising anti-CSC agent. However, an explicit mechanism of action has not yet been characterized, in particular due to the pleiotropic responses salinomycin is known for. In this punctum, we describe our recent discovery that salinomycin and the more potent synthetic derivative we named ironomycin sequester lysosomal iron. We found that these compounds, by blocking iron translocation, induce an iron-depletion response leading to a lysosomal degradation of ferritin followed by an iron-mediated lysosomal production of reactive oxygen species (ROS) and a cell death pathway that resembles ferroptosis. These unprecedented findings identified iron homeostasis and iron-mediated processes as potentially druggable in the context of CSCs.
Our most eerie and popular tour is back! This 2-hour walking tour begins at the Iron Hand Brewery where guests can enjoy a hand crafted brew before we begin our tales of darkness, death, and dismemberment. The walking is easy, but the stories are dark as we explore pre-Civil War mansions, ov